Genetic mutations aren't the only thing that can keep a protein called PTEN from doing its tumor-suppressing job. Johns Hopkins researchers have now discovered that four small chemical tags attached (reversibly) to the protein's tail can have the same effect, and they say their finding may offer a novel path for drug design to keep PTEN working.
Researchers from the National Environmental Engineering Research Institute in Nehru Marg, India have added another piece to the puzzle of how to synthetize an artificial nicotine receptor. One of the most long-lasting goals of biomedical science and technology is to design and synthesize efficient artificial receptors that would point to new avenues in the treatment of addiction.
Researchers at the London Centre of Nanotechnology and Universities of Bristol and Southampton have made a distinctive step towards the understanding of bacterial resistance to ribosome-targeting antibiotics.
A cellular control mechanism prevents the production of defective proteins in our cells. A team of researchers from Bern has now obtained valuable insights into this vital mechanism that could lead to new therapeutic approaches for genetic diseases.
There is growing research of hydrogels, the gelatinous substance that, because of its toughness and plasticity, has several biomedical applications, including cartilage repair, implants for minimally invasive surgery and drug delivery.
Researchers have determined that the transcription factor Nanog, which plays a critical role in the self-renewal of embryonic stem cells, is expressed in a manner similar to other pluripotency markers. This finding contradicts the field's presumptions about this important gene and its role in the differentiation of embryonic stem cells.
Transport proteins are responsible for moving materials such as nutrients and metabolic products through a cell's outer membrane, which seals and protects all living cells, to the cell's interior. A team has now developed a groundbreaking new way to measure the activity of transporter proteins in living organisms.
Knowing virtually everything about how the body's cells make transitions from one state to another - for instance, precisely how particular cells develop into multi-cellular organisms - would be a major jump forward in understanding the basics of what drives biological processes.