A protein associated with neuron damage in Alzheimer's patients provides a superior scaffold for growing central nervous system cells in the lab. The findings could have clinical implications for producing neural implants and offers new insights on the complex link between the apoE4 apolipoprotein and Alzheimer's disease.
60 years after Watson and Crick's ground breaking paper described the double helix structure of DNA, researchers at the University of Cambridge have observed four-stranded DNA structures within human cells. The discovery could open the door to novel cancer therapies and a new era for personalised medicine.
Scientists have developed a way to grow iron-oxidizing bacteria using electricity instead of iron, an advance that will allow them to better study the organisms and could one day be used to turn electricity into fuel.
Scientists from Karolinska Institutet in Sweden have made progress in understanding how human genes are regulated. In their study they have identified the DNA sequences, which bound to over four hundred proteins controlling the expression of genes.
In biology, molecules can have multi-way interactions within cells, and until recently, computational analysis of these links has been "incomplete," according to T. M. Murali, associate professor of computer science in the College of Engineering at Virginia Tech. His group authored an article on their new approach to address these shortcomings.
After years of experimentation, researchers at the University of Arkansas have solved a complex, decades-old problem in membrane biochemistry. The consequence of their work will give scientists more information about the function and structure of proteins, the workhorses within the cells of the human body.
With projections of 9.5 billion people by 2050, humankind faces the challenge of feeding modern diets to additional mouths while using the same amounts of water, fertilizer and arable land as today. Cornell researchers have taken a leap toward meeting those needs by discovering a gene that could lead to new varieties of staple crops with 50 percent higher yields.
Scientists at the SUNY College of Environmental Science and Forestry (ESF) are developing a biochemical process that uses a protein molecule to disrupt the process by which bacteria become virulent, a finding that could have widespread implications for human health.
While working out the structure of a cell-killing protein produced by some strains of the bacterium Enterococcus faecalis, researchers stumbled on a bit of unusual biochemistry. They found that a single enzyme helps form distinctly different, three-dimensional ring structures in the protein, one of which had never been observed before.
A new metabolic engineering tool that allows fine control of gene expression level by employing synthetic small regulatory RNAs was developed to efficiently construct microbial cell factories producing desired chemicals and materials.
Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna, Austria and at the University of Cologne, Germany have discovered the molecular basis underlying the patterned folding and assembly of muscle proteins.