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How bacteria integrate autotransporters into their outer membrane

The bacterial outer envelope is densely packed with proteins that form small pores and facilitate the passage of nutrients, toxins and signaling molecules. Professors Timm Maier and Sebastian Hiller from the Biozentrum of the University of Basel now demonstrate how these transporter proteins are integrated into the outer membrane.

Posted: Sep 23rd, 2013

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A revolutionary new method for discovering antibiotics

Biologists at the University of California, San Diego have developed a revolutionary new method for identifying and characterizing antibiotics, an advance that could lead to the discovery of new antibiotics to treat antibiotic resistant bacteria.

Posted: Sep 18th, 2013

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Signal gradients in 3-D guide stem cell behavior

Researchers at Case Western Reserve University have developed an easy and versatile way of forming physical and biochemical gradients in three dimensions -- a step toward identifying the recipes that induce stem cells to generate specific tissues, including multiple tissues, such as a bone-cartilage interface. Ultimately, one of their goals is to engineer systems to manipulate stem cells to repair or replace damaged tissues and organs.

Posted: Sep 18th, 2013

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Chemistry magic promises better medicine with fewer side-effects

A gentler new chemistry promises cleaner and subsequently far safer pharmaceuticals. Knud J. Jensen, who developed the ground-breaking method at the University of Copenhagen, is convinced that the method will become pivotal in the development of new pharmaceuticals.

Posted: Sep 16th, 2013

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Chemists develop switchable antibiotic

Scientists at the University of Groningen have developed an antibiotic whose activity can be controlled using light. It is possible to 'switch on' the substance immediately before use, after which it will slowly lose its activity.

Posted: Sep 16th, 2013

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Molecular structure reveals how HIV infects cells

A team of Chinese and US scientists has determined the high-resolution atomic structure of a cell-surface receptor that most strains of HIV use to get into human immune cells. The researchers also showed where maraviroc, an HIV drug, attaches to cells and blocks HIV's entry.

Posted: Sep 12th, 2013

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Marine biotechnology opens new channels to innovative bioproducts for human health

On September 12th in her inaugural address upon taking up the post of Special Professor of Marine Biotechnology at Wageningen University Prof. Dr Shirley Pomponi will present how marine animals use a broad range of fine chemicals to defend themselves against infection, overgrowing and other threats. Her effort is to identify these chemicals, to let them be produced in a sustainable way and to develop innovative bioproducts for human health.

Posted: Sep 12th, 2013

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