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Study tests precision of protein 'machine'

Since its discovery, researchers have hailed Cas9 - a protein 'machine' that can be programmed by a strand of RNA to target specific DNA sequences and to precisely cut, paste, and turn on or turn off genes - as a potential key to unlocking a host of new treatments and therapies for genetic conditions, but only if they fully understand how it works.

Posted: Sep 26th, 2013

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Scientists produce induced pluripotent stem cells by removing one protein

Reprogramming adult stem cells so that they are like embryonic stem cells has the potential to change medicine; however, the reprogramming process is inefficient and impractical. Now, Dr. Yaqub Hanna has found that removing one protein changes everything, raising the efficiency of this reprogramming from one percent or less to 100 percent.

Posted: Sep 23rd, 2013

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Algae researchers partner to develop bioactive molecules

Researchers at the Arizona Center for Algae Technology and Innovation and the ASU-led Algae Testbed Public-Private Partnership have made a one-year agreement with Health Enhancement Products, Inc., which investigates and licenses algae-derived, high-value bioactive molecules that benefit human and animal health.

Posted: Sep 23rd, 2013

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How bacteria integrate autotransporters into their outer membrane

The bacterial outer envelope is densely packed with proteins that form small pores and facilitate the passage of nutrients, toxins and signaling molecules. Professors Timm Maier and Sebastian Hiller from the Biozentrum of the University of Basel now demonstrate how these transporter proteins are integrated into the outer membrane.

Posted: Sep 23rd, 2013

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A revolutionary new method for discovering antibiotics

Biologists at the University of California, San Diego have developed a revolutionary new method for identifying and characterizing antibiotics, an advance that could lead to the discovery of new antibiotics to treat antibiotic resistant bacteria.

Posted: Sep 18th, 2013

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Signal gradients in 3-D guide stem cell behavior

Researchers at Case Western Reserve University have developed an easy and versatile way of forming physical and biochemical gradients in three dimensions -- a step toward identifying the recipes that induce stem cells to generate specific tissues, including multiple tissues, such as a bone-cartilage interface. Ultimately, one of their goals is to engineer systems to manipulate stem cells to repair or replace damaged tissues and organs.

Posted: Sep 18th, 2013

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Chemistry magic promises better medicine with fewer side-effects

A gentler new chemistry promises cleaner and subsequently far safer pharmaceuticals. Knud J. Jensen, who developed the ground-breaking method at the University of Copenhagen, is convinced that the method will become pivotal in the development of new pharmaceuticals.

Posted: Sep 16th, 2013

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Chemists develop switchable antibiotic

Scientists at the University of Groningen have developed an antibiotic whose activity can be controlled using light. It is possible to 'switch on' the substance immediately before use, after which it will slowly lose its activity.

Posted: Sep 16th, 2013

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