Our DNA and its architecture are duplicated every time our cells divide. Histone proteins are key building blocks of this architecture and contain gene regulatory information. Danish researchers show how an enzyme controls reliable and high-speed delivery of histones to DNA copying hubs in our cells. This shuttling mechanism is crucial to maintain normal function of our genes and prevent diseases as cancer.
Like mobsters following strict orders, newly engineered molecules called 'ubiquibodies' can mark specific proteins inside a cell for destruction. It's a molecular kiss of death developed at Cornell University that is paving the way for new drug therapies and powerful research tools.
Scientists at The Scripps Research Institute have invented small-molecule folding probes that enable them to quantify functional, normally folded and disease-associated misfolded conformations (shapes) of a protein-of-interest in cells under different conditions.
Researchers have developed a new method that allows scientists to pinpoint thousands of mRNAs and other types of RNAs at once in intact cells - all while determining the sequence of letters, or bases, that identify them and reveal what they do.
At Deutsches Elektronen-Synchrotron's PETRA III research light source, scientists have carried out the first studies of living biological cells using high-energy X-rays. The new method for the first time enables us to investigate the internal structures of living cells in their natural environment using hard X-rays.
Chemists from Radboud University Nijmegen and the Foundation for Fundamental Research on Matter (FOM) have succeeded in producing detailed 3D structures of selected peptides - the building blocks of proteins.
Scientists have made an important breakthrough: they have discovered a way to transform skin cells into mature, fully functioning liver cells that flourish on their own, even after being transplanted into laboratory animals modified to mimic liver failure.
A new bioprinting method developed at the Wyss Institute for Biologically Inspired Engineering at Harvard University and the Harvard School of Engineering and Applied Sciences creates intricately patterned 3-D tissue constructs with multiple types of cells and tiny blood vessels. The work represents a major step toward a longstanding goal of tissue engineers: creating human tissue constructs realistic enough to test drug safety and effectiveness.